Belford AK, Maurer JB, Duda RL, Huet A, Conway JF. (2025) Structural insights into scaffold-guided assembly of the Pseudomonas phage D3 capsid. Nat Commun 16, 11586. PMCID: PMC12749128. doi: 10.1038/s41467-025-66648-1
Huang H, Mu Y, Yixian Y, Ji B, Wang Y, Chen C-Y, Chen Y, Luo Z, Li S, Zhang Z, Wang L, Conway JF, Yang D, Wang J, Sun J & Li S. (2025) Rational development of gemcitabine-based nanoplatform for targeting SERPINB9/Granzyme B axis to overcome chemo-immune-resistance. Nat Commun 16, 4176. PMCID: PMC12053578. DOI: 10.1038/s41467-025-59490-y
Hansen KH, Golcuk M, Byeon CH, Tunc1 A, Plechinger EB, Dueholm MKD, Conway JF, Andreasen M, Gur M, Akbey Ü. (2025) Structural basis of Pseudomonas biofilm-forming functional amyloid FapC formation. Sci Adv 11, eadx7829. PMCID: PMC12459412. DOI: 10.1126/sciadv.adx7829
Freeman KG, Mondal S, Macale LS, White SJ, Podgorski J, Silva B, Ortiz V, Huet A, Narsico JT, Ho M-C, Lowary T, Conway JF, Park D & Hatfull GF (2025) Structure and infection dynamics of mycobacteriophage Bxb1. Cell, S0092-8674(25)00345-9. PMCID: PMC12124961. DOI: 10.1016/j.cell.2025.03.027
Wieteska Ł, Taylor AB, Punch E, Coleman JA, Conway IO, Lin YF, Byeon CH, Hinck CS, Krzysiak T, Ishima R, López-Casillas F, Cherepanov P, Bernard DJ, Hill CS, Hinck AP. (2025) Structures of TGF-β with betaglycan and signaling receptors reveal mechanisms of complex assembly and signaling. Nat Commun 16, 1778. PMCID: PMC11865472. DOI: 10.1038/s41467-025-56796-9
Vergara S, Zhou X, Santiago U, Alaoui-El-Azher M, Conway JF, Sluis-Cremer N & Calero G (2024) Structural basis of deoxynucleotide addition by HIV-1 RT during reverse transcription. Nat Commun 15, 10553. PMCID: PMC11618517. DOI: 10.1038/s41467-024-54618-y
Werner Lass S, Smith BE, Camphire S, Eutsey RA, Prentice JA, Yerneni SS, Arun A, Bridges AA, Rosch JW, Conway JF, Campbell P, Hiller NL (2024) Pneumococcal extracellular vesicles mediate horizontal gene transfer via the transformation machinery. mSphere 9, e0072724. PMCID: PMC11656791. DOI: 10.1128/msphere.00727-24
Hansen KH, Byeon CH, Liu Q, Drace T, Boesen T, Conway JF, Andreasen M & Akbey Ü (2024) Structure of biofilm-forming functional amyloid PSMa1 from Staphylococcus aureus. PNAS 121, e2406775121. PMCID: PMC11331129. DOI: 10.1073/pnas.2406775121
Eren E, Watts NR, Conway JF & Wingfield PT (2024) Myxococcus xanthus Encapsulin Cargo Protein EncD is Flavin-Binding Protein with Ferric Reductase Activity. PNAS 121, e2400426121. PMCID: PMC11126975. DOI: 10.1073/pnas.2400426121
Luo Z, Huang Y, Batra N, Chen Y, Huang H, Wang Y, Zhang Z, Li S, Chen CY, Wang Z, Sun J, Wang QJ, Yang D, Lu B, Conway JF, Li LY, Yu AM & Li S (2024) Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy. Nat Commun. 15:255. PMCID: PMC10766965. DOI: 10.1038/s41467-023-44572-6
Khare P, Edgecomb SX, Hamadani CM, Conway JF, Tanner EEL & Manickam DS (2024) Ionic liquid-coated lipid nanoparticles increase siRNA uptake into CNS targets. Nanoscale advances 6, 1853-1873. DOI: 10.1039/d3na00699a
Huet A, Oh B, Maurer J, Duda RL & Conway JF (2023) A symmetry mismatch unraveled: How phage HK97 scaffold flexibly accommodates a 12-fold pore at a 5-fold viral capsid vertex. Sci Adv 9, eadg8868. PMCID: PMC10275583. DOI: 10.1126/sciadv.adg8868
Chen Y, Huang Y, Li Q, Luo Z, Zhang Z, Huang H, Sun J, Zhang L, Sun R, Bain DJ, Conway JF, Lu B & Li S (2023) Targeting Xkr8 via nanoparticle-mediated in situ co-delivery of siRNA and chemotherapy drugs for cancer immunochemotherapy. Nat Nanotechnol. 18, 193-204. PMCID: PMC9974593. DOI: 10.1038/s41565-022-01266-2
Hawkins DEDP, Bayfield OW, Fung HKH, Grba DN, Huet A, Conway JF & Antson AA (2023) Insights into a viral motor: the structure of the HK97 packaging termination assembly. Nucleic Acids Res. 51, 7025-7035. PMCID: PMC10359639. DOI: 10.1093/nar/gkad480
Podgorski JM, Freeman K, Gosselin S, Huet A, Conway JF, Bird M, Grecco J, Patel S, Jacobs-Sera D, Hatfull G, Gogarten JP, Ravantti J & White SJ (2023) A structural dendrogram of the actinobacteriophage major capsid proteins provides important structural insights into the evolution of capsid stability. Structure 31, 282-294.e5. PMCID: PMC10071307. DOI: 10.1016/j.str.2022.12.012
Khare P, Conway JF & S Manickam D (2022) Lipidoid nanoparticles increase ATP uptake into hypoxic brain endothelial cells. Eur J Pharm Biopharm. 180, 238-250. DOI: 10.1016/j.ejpb.2022.10.011
Fung HKH, Grimes S, Huet A, Duda RL, Chechik M, Gault J, Robinson CV, Hendrix RW, Jardine PJ, Conway JF, Baumann CG & Antson AA. (2022) Structural basis of DNA packaging by a ring-type ATPase from an archetypal viral system. Nucleic Acids Res. 50, 8719-8732. PMCID: PMC9410871. DOI: 10.1093/nar/gkac647
Sun D, Sang Z, Kim YJ, Xiang Y, Cohen T, Belford AK, Huet A, Conway JF, Sun J, Taylor DJ, Schneidman-Duhovny D, Zhang C, Huang W & Shi Y (2021) Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes. Nat Commun 12, 4676. PMCID: PMC8333356. DOI: 10.1038/s41467-021-24963-3
Strubbe-Rivera JO, Schrad JR, Pavlov EV, Conway JF, Parent KN & Bazil JN (2021) The mitochondrial permeability transition phenomenon elucidated by cryo-EM reveals the genuine impact of calcium overload on mitochondrial structure and function. Sci Rep 11, 1037. PMCID: PMC7806632. DOI: 10.1038/s41598-020-80398-8
Goetschius DJ, Hartmann SR, Organtini LJ, Callaway H, Huang K, Bator CM, Ashley RE, Makhov AM, Conway JF, Parrish CR & Hafenstein SL (2021) High-resolution asymmetric structure of a Fab-virus complex reveals overlap with the receptor binding site. PNAS USA 118, e2025452118. PMCID: PMC8201801. DOI: 10.1073/pnas.2025452118
Campbell PL, Duda RL, Nassur J, Conway JF & Huet A (2020) Mobile Loops and Electrostatic Interactions Maintain the Flexible Tail Tube of Bacteriophage Lambda. J Mol Biol. 432, 384-395. PMCID: PMC7575002. DOI: 10.1016/j.jmb.2019.10.031
Boatz JC, Piretra T, Lasorsa A, Matlahov I, Conway JF & van der Wel PCA (2020) Protofilament Structure and Supramolecular Polymorphism of Aggregated Mutant Huntingtin Exon 1. J Mol Biol 432, 4722-4744. PMCID: PMC8170701. DOI: 10.1016/j.jmb.2020.06.021
Huet A, Huffman JB, Conway JF & Homa FL (2020) Role of the herpes simplex virus CVSC proteins at the capsid portal vertex. J Virol 94, e01534-20. PMC7925205. DOI: 10.1128/JVI.01534-20
Spiriti J, Conway JF & Zuckerman DM (2020) Should Virus Capsids Assemble Perfectly? Theory and Observation of Defects. Biophys J. 119, 1781-1790. PMCID: PMC7677133. DOI: 10.1016/j.bpj.2020.09.021
Huet A, Duda RL, Boulanger P & Conway JF (2019) Capsid expansion of bacteriophage T5 revealed by high resolution cryoelectron microscopy. PNAS 116, 21037-21046. PMCID: PMC6800373. DOI: 10.1128/JVI.01534-20
Hua J, Huet A, Lopez CA, Toropova K, Pope WH, Duda RL, Hendrix RW & Conway JF (2017) Capsids and genomes of jumbo-sized bacteriophages reveal the evolutionary reach of the HK97 fold. mBio 8, e01579-17. PMCID: PMC5646251. DOI: 10.1128/mBio.01579-17
Stevenson HP, Lin G, Barnes CO, Sutkeviciute I, Krzysiak T, Weiss SC, Reynolds S, Wu Y, Nagarajan V, Makhov AM, Lawrence R, Lamm E, Clark L, Gardella TJ, Hogue BG, Ogata CM, Ahn J, Gronenborn AM, Conway JF, Vilardaga JP, Cohen AE & Calero G (2016) Transmission electron microscopy for the evaluation and optimization of crystal growth. Acta Crystallogr D Struct Biol 72, 603-615. PMCID: PMC4854312. DOI: 10.1107/S2059798316001546
Lee H, Shingler KL, Organtini LJ, Ashley RE, Subramanium S, Makhov AM, Conway JF & Hafenstein S (2016) The novel asymmetric entry intermediate of a picornavirus captured with nanodiscs. Science Advances 2, e1501929. PMCID: PMC4996645. DOI: 10.1126/sciadv.1501929
Huet A, Makhov AM, Huffman JB, Vos M, Homa FL & Conway JF (2016) Extensive subunit contacts underpin herpesvirus capsid stability and interior-to-exterior allostery. Nat Struct Mol Biol 23, 531-539, 2016. PMCID: PMC4899274. DOI: 10.1038/nsmb.3212
Shingler KL, Cifuente JO, Ashley RE, Makhov AM, Conway JF & Hafenstein S (2015) The enterovirus 71 procapsid binds neutralizing antibodies and rescues virus infection in vitro. J Virol 89, 1900-1908. PMCID: PMC4300772. DOI: 10.1128/JVI.03098-14
Shingler KL, Yoder JL, Carnegie MS, Ashley RE, Makhov AM, Conway JF & Hafenstein S (2013) The enterovirus 71 A-particle forms a gateway to allow genome release: a cryoem study of picornavirus uncoating. PLoS Pathog 9: e1003240. PMCID: PMC3605244. DOI: 10.1371/journal.ppat.1003240
Homa FL, Huffman JB, Toropova K, Lopez HR, Makhov AM & Conway JF (2013) Structure of the pseudorabies virus capsid: comparison with herpes simplex virus type 1 and differential binding of essential minor proteins. J Mol Biol 425, 3415-3428. PMCID: PMC3779361. DOI: 10.1016/j.jmb.2013.06.034
Toropova K, Huffman JB, Homa FL & Conway JF (2011) The herpes simplex virus 1 UL17 protein is the second constituent of the capsid vertex-specific component required for DNA packaging and retention. J Virol 85, 7513-7522. PMCID: PMC3147944. DOI: 10.1128/JVI.00837-11
Watts NR, Conway JF, Cheng N, Stahl SJ, Steven AC & Wingfield PT (2011) Role of the propeptide in controlling conformation and assembly state of hepatitis B virus e-antigen. J Mol Biol 409, 202-213. PMCID: PMC3095675. DOI: 10.1016/j.jmb.2011.03.049
Conway JF, Watts NR, Belnap DM, Cheng N, Stahl SJ, Wingfield PT & Steven AC (2003) Characterization of a conformational epitope on hepatitis B virus core antigen and quasiequivalent variations in antibody binding. J Virol 77, 6466-6473. PMCID: PMC155010. DOI: 10.1128/jvi.77.11.6466-6473.2003
Conway JF, Wikoff WR, Cheng N, Duda RL, Hendrix RW, Johnson JE & Steven AC (2001) Virus maturation involving large subunit rotations and local refolding. Science 292, 744-748. PMID: 11326105. DOI: 10.1126/science.1058069
Conway JF & Steven AC (1999) Methods for reconstructing density maps of single particles from cryoelectron micrographs to subnanometer resolution. J Struct Biol 128, 106-118. PMID: 10600565. DOI: 10.1006/jsbi.1999.4168
Conway JF, Cheng N, Zlotnick A, Wingfield PT, Stahl SJ & Steven AC (1997) Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryo-electron microscopy. Nature 386, 91-94, PMID: 9052787. DOI: 10.1038/386091a0