{"id":15,"date":"2023-09-18T14:29:47","date_gmt":"2023-09-18T14:29:47","guid":{"rendered":"http:\/\/conwaylab.structbio.pitt.edu\/?page_id=15"},"modified":"2026-01-04T15:20:17","modified_gmt":"2026-01-04T15:20:17","slug":"publications","status":"publish","type":"page","link":"https:\/\/conwaylab.structbio.pitt.edu\/index.php\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/james.conway.1\/bibliography\/public\/\" target=\"_blank\" rel=\"noopener noreferrer\"><u>Full List &lt;link&gt;<\/u><\/a><\/p>\n<ul>\n<li>Belford AK, Maurer JB, Duda RL, Huet A, Conway JF. (2025) Structural insights into scaffold-guided assembly of the Pseudomonas phage D3 capsid. Nat Commun 16, 11586. PMCID: PMC12749128. doi: <a href=\"https:\/\/doi.org\/10.1038\/s41467-025-66648-1\">10.1038\/s41467-025-66648-1<\/a><\/li>\n<li>Huang H, Mu Y, Yixian Y, Ji B, Wang Y, Chen C-Y, Chen Y, Luo Z, Li S, Zhang Z, Wang L, Conway JF, Yang D, Wang J, Sun J &amp; Li S. (2025) Rational development of gemcitabine-based nanoplatform for targeting SERPINB9\/Granzyme B axis to overcome chemo-immune-resistance. Nat Commun 16, 4176. PMCID: PMC12053578. DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41467-025-59490-y\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/s41467-025-59490-y<\/a><\/li>\n<li>Hansen KH, Golcuk M, Byeon CH, Tunc1 A, Plechinger EB, Dueholm MKD, Conway JF, Andreasen M, Gur M, Akbey \u00dc. (2025) Structural basis of Pseudomonas biofilm-forming functional amyloid FapC formation. Sci Adv 11, eadx7829. PMCID: PMC12459412. DOI: <a href=\"https:\/\/doi.org\/10.1126\/sciadv.adx7829\" target=\"_blank\" rel=\"noopener noreferrer\">10.1126\/sciadv.adx7829<\/a><\/li>\n<li>Freeman KG, Mondal S, Macale LS, White SJ, Podgorski J, Silva B, Ortiz V, Huet A, Narsico JT, Ho M-C, Lowary T, Conway JF, Park D &amp; Hatfull GF (2025) Structure and infection dynamics of mycobacteriophage Bxb1. Cell, S0092-8674(25)00345-9. PMCID: PMC12124961. DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41586-025-09186-6\" target=\"_blank\" rel=\"noopener noreferrer\">10.1016\/j.cell.2025.03.027<\/a><\/li>\n<li>Wieteska \u0141, Taylor AB, Punch E, Coleman JA, Conway IO, Lin YF, Byeon CH, Hinck CS, Krzysiak T, Ishima R, L\u00f3pez-Casillas F, Cherepanov P, Bernard DJ, Hill CS, Hinck AP. (2025) Structures of TGF-\u03b2 with betaglycan and signaling receptors reveal mechanisms of complex assembly and signaling. Nat Commun 16, 1778. PMCID: PMC11865472. DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41467-025-56796-9\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/s41467-025-56796-9<\/a><\/li>\n<li>Vergara S, Zhou X, Santiago U, Alaoui-El-Azher M, Conway JF, Sluis-Cremer N &amp; Calero G (2024) Structural basis of deoxynucleotide addition by HIV-1 RT during reverse transcription. Nat Commun 15, 10553. PMCID: PMC11618517. DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41467-024-54618-y\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/s41467-024-54618-y<\/a><\/li>\n<li>Werner Lass S, Smith BE, Camphire S, Eutsey RA, Prentice JA, Yerneni SS, Arun A, Bridges AA, Rosch JW, Conway JF, Campbell P, Hiller NL (2024) Pneumococcal extracellular vesicles mediate horizontal gene transfer via the transformation machinery. mSphere 9, e0072724. PMCID: PMC11656791. DOI: <a href=\"https:\/\/doi.org\/10.1128\/msphere.00727-24\" target=\"_blank\" rel=\"noopener noreferrer\">10.1128\/msphere.00727-24<\/a><\/li>\n<li>Hansen KH, Byeon CH, Liu Q, Drace T, Boesen T, Conway JF, Andreasen M &amp; Akbey \u00dc (2024) Structure of biofilm-forming functional amyloid PSMa1 from <em>Staphylococcus aureus<\/em>. PNAS 121, e2406775121. PMCID: PMC11331129. DOI: <a href=\"https:\/\/doi.org\/10.1073\/pnas.2406775121\" target=\"_blank\" rel=\"noopener noreferrer\">10.1073\/pnas.2406775121<\/a><\/li>\n<li>Eren E, Watts NR, Conway JF &amp; Wingfield PT (2024) <em>Myxococcus xanthus<\/em> Encapsulin Cargo Protein EncD is Flavin-Binding Protein with Ferric Reductase Activity. PNAS 121, e2400426121. PMCID: PMC11126975. DOI: <a href=\"https:\/\/doi.org\/10.1073\/pnas.2400426121\" target=\"_blank\" rel=\"noopener noreferrer\">10.1073\/pnas.2400426121<\/a><\/li>\n<li>Luo Z, Huang Y, Batra N, Chen Y, Huang H, Wang Y, Zhang Z, Li S, Chen CY, Wang Z, Sun J, Wang QJ, Yang D, Lu B, Conway JF, Li LY, Yu AM &amp; Li S (2024) Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy. Nat Commun. 15:255. PMCID: PMC10766965. DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41467-023-44572-6\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/s41467-023-44572-6<\/a><\/li>\n<li>Khare P, Edgecomb SX, Hamadani CM, Conway JF, Tanner EEL &amp; Manickam DS (2024) Ionic liquid-coated lipid nanoparticles increase siRNA uptake into CNS targets. Nanoscale advances 6, 1853-1873. DOI: <a href=\"https:\/\/doi.org\/10.1039\/d3na00699a\" target=\"_blank\" rel=\"noopener noreferrer\">10.1039\/d3na00699a<\/a><\/li>\n<li>Huet A, Oh B, Maurer J, Duda RL &amp; Conway JF (2023) A symmetry mismatch unraveled: How phage HK97 scaffold flexibly accommodates a 12-fold pore at a 5-fold viral capsid vertex. Sci Adv 9, eadg8868. PMCID: PMC10275583. DOI: <a href=\"https:\/\/doi.org\/10.1126\/sciadv.adg8868\" target=\"_blank\" rel=\"noopener noreferrer\">10.1126\/sciadv.adg8868<\/a><\/li>\n<li>Chen Y, Huang Y, Li Q, Luo Z, Zhang Z, Huang H, Sun J, Zhang L, Sun R, Bain DJ, Conway JF, Lu B &amp; Li S (2023) Targeting Xkr8 via nanoparticle-mediated in situ co-delivery of siRNA and chemotherapy drugs for cancer immunochemotherapy. Nat Nanotechnol. 18, 193-204. PMCID: PMC9974593. DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41565-022-01266-2\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/s41565-022-01266-2<\/a><\/li>\n<li>Hawkins DEDP, Bayfield OW, Fung HKH, Grba DN, Huet A, Conway JF &amp; Antson AA (2023) Insights into a viral motor: the structure of the HK97 packaging termination assembly. Nucleic Acids Res. 51, 7025-7035. PMCID: PMC10359639. DOI: <a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad480\" target=\"_blank\" rel=\"noopener noreferrer\">10.1093\/nar\/gkad480<\/a><\/li>\n<li>Podgorski JM, Freeman K, Gosselin S, Huet A, Conway JF, Bird M, Grecco J, Patel S, Jacobs-Sera D, Hatfull G, Gogarten JP, Ravantti J &amp; White SJ (2023) A structural dendrogram of the actinobacteriophage major capsid proteins provides important structural insights into the evolution of capsid stability. Structure 31, 282-294.e5. PMCID: PMC10071307. DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.str.2022.12.012\" target=\"_blank\" rel=\"noopener noreferrer\">10.1016\/j.str.2022.12.012<\/a><\/li>\n<li>Khare P, Conway JF &amp; S Manickam D (2022) Lipidoid nanoparticles increase ATP uptake into hypoxic brain endothelial cells. Eur J Pharm Biopharm. 180, 238-250. DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.ejpb.2022.10.011\" target=\"_blank\" rel=\"noopener noreferrer\">10.1016\/j.ejpb.2022.10.011<\/a><\/li>\n<li>Fung HKH, Grimes S, Huet A, Duda RL, Chechik M, Gault J, Robinson CV, Hendrix RW, Jardine PJ, Conway JF, Baumann CG &amp; Antson AA. (2022) Structural basis of DNA packaging by a ring-type ATPase from an archetypal viral system. Nucleic Acids Res. 50, 8719-8732. PMCID: PMC9410871. DOI: <a href=\"https:\/\/doi.org\/10.1093\/nar\/gkac647\" target=\"_blank\" rel=\"noopener noreferrer\">10.1093\/nar\/gkac647<\/a><\/li>\n<li>Sun D, Sang Z, Kim YJ, Xiang Y, Cohen T, Belford AK, Huet A, Conway JF, Sun J, Taylor DJ, Schneidman-Duhovny D, Zhang C, Huang W &amp; Shi Y (2021) Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes. Nat Commun 12, 4676. PMCID: PMC8333356. DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41467-021-24963-3\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/s41467-021-24963-3<\/a><\/li>\n<li>Strubbe-Rivera JO, Schrad JR, Pavlov EV, Conway JF, Parent KN &amp; Bazil JN (2021) The mitochondrial permeability transition phenomenon elucidated by cryo-EM reveals the genuine impact of calcium overload on mitochondrial structure and function. Sci Rep 11, 1037. PMCID: PMC7806632. DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41598-020-80398-8\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/s41598-020-80398-8<\/a><\/li>\n<li>Goetschius DJ, Hartmann SR, Organtini LJ, Callaway H, Huang K, Bator CM, Ashley RE, Makhov AM, Conway JF, Parrish CR &amp; Hafenstein SL (2021) High-resolution asymmetric structure of a Fab-virus complex reveals overlap with the receptor binding site. PNAS USA 118, e2025452118. PMCID: PMC8201801. DOI: <a href=\"https:\/\/doi.org\/10.1073\/pnas.2025452118\" target=\"_blank\" rel=\"noopener noreferrer\">10.1073\/pnas.2025452118<\/a><\/li>\n<li>Campbell PL, Duda RL, Nassur J, Conway JF &amp; Huet A (2020) Mobile Loops and Electrostatic Interactions Maintain the Flexible Tail Tube of Bacteriophage Lambda. J Mol Biol. 432, 384-395. PMCID: PMC7575002. DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.jmb.2019.10.031\" target=\"_blank\" rel=\"noopener noreferrer\">10.1016\/j.jmb.2019.10.031<\/a><\/li>\n<li>Boatz JC, Piretra T, Lasorsa A, Matlahov I, Conway JF &amp; van der Wel PCA (2020) Protofilament Structure and Supramolecular Polymorphism of Aggregated Mutant Huntingtin Exon 1. J Mol Biol 432, 4722-4744. PMCID: PMC8170701. DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.jmb.2020.06.021\" target=\"_blank\" rel=\"noopener noreferrer\">10.1016\/j.jmb.2020.06.021<\/a><\/li>\n<li>Huet A, Huffman JB, Conway JF &amp; Homa FL (2020) Role of the herpes simplex virus CVSC proteins at the capsid portal vertex. J Virol 94, e01534-20. PMC7925205. DOI: <a href=\"https:\/\/doi.org\/10.1128\/jvi.01534-20\" target=\"_blank\" rel=\"noopener noreferrer\">10.1128\/JVI.01534-20<\/a><\/li>\n<li>Spiriti J, Conway JF &amp; Zuckerman DM (2020) Should Virus Capsids Assemble Perfectly? Theory and Observation of Defects. Biophys J. 119, 1781-1790. PMCID: PMC7677133. DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.bpj.2020.09.021\" target=\"_blank\" rel=\"noopener noreferrer\">10.1016\/j.bpj.2020.09.021<\/a><\/li>\n<li>Huet A, Duda RL, Boulanger P &amp; Conway JF (2019) Capsid expansion of bacteriophage T5 revealed by high resolution cryoelectron microscopy. PNAS 116, 21037-21046. PMCID: PMC6800373. DOI: <a href=\"https:\/\/doi.org\/10.1128\/jvi.01534-20\" target=\"_blank\" rel=\"noopener noreferrer\">10.1128\/JVI.01534-20<\/a><\/li>\n<li>Hua J, Huet A, Lopez CA, Toropova K, Pope WH, Duda RL, Hendrix RW &amp; Conway JF (2017) Capsids and genomes of jumbo-sized bacteriophages reveal the evolutionary reach of the HK97 fold. mBio 8, e01579-17. PMCID: PMC5646251. DOI: <a href=\"https:\/\/doi.org\/10.1128\/mbio.01579-17\" target=\"_blank\" rel=\"noopener noreferrer\">10.1128\/mBio.01579-17<\/a><\/li>\n<li>Stevenson HP, Lin G, Barnes CO, Sutkeviciute I, Krzysiak T, Weiss SC, Reynolds S, Wu Y, Nagarajan V, Makhov AM, Lawrence R, Lamm E, Clark L, Gardella TJ, Hogue BG, Ogata CM, Ahn J, Gronenborn AM, Conway JF, Vilardaga JP, Cohen AE &amp; Calero G (2016) Transmission electron microscopy for the evaluation and optimization of crystal growth. Acta Crystallogr D Struct Biol 72, 603-615. PMCID: PMC4854312. DOI: <a href=\"https:\/\/doi.org\/10.1107\/s2059798316001546\">10.1107\/S2059798316001546<\/a><\/li>\n<li>Lee H, Shingler KL, Organtini LJ, Ashley RE, Subramanium S, Makhov AM, Conway JF &amp; Hafenstein S (2016) The novel asymmetric entry intermediate of a picornavirus captured with nanodiscs. Science Advances 2, e1501929. PMCID: PMC4996645. DOI: <a href=\"https:\/\/doi.org\/10.1126\/sciadv.1501929\" target=\"_blank\" rel=\"noopener noreferrer\">10.1126\/sciadv.1501929<\/a><\/li>\n<li>Huet A, Makhov AM, Huffman JB, Vos M, Homa FL &amp; Conway JF (2016) Extensive subunit contacts underpin herpesvirus capsid stability and interior-to-exterior allostery. Nat Struct Mol Biol 23, 531-539, 2016. PMCID: PMC4899274. DOI: <a href=\"https:\/\/doi.org\/10.1038\/nsmb.3212\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/nsmb.3212<\/a><\/li>\n<li>Shingler KL, Cifuente JO, Ashley RE, Makhov AM, Conway JF &amp; Hafenstein S (2015) The enterovirus 71 procapsid binds neutralizing antibodies and rescues virus infection in vitro. J Virol 89, 1900-1908. PMCID: PMC4300772. DOI: <a href=\"https:\/\/doi.org\/10.1128\/jvi.03098-14\" target=\"_blank\" rel=\"noopener noreferrer\">10.1128\/JVI.03098-14<\/a><\/li>\n<li>Shingler KL, Yoder JL, Carnegie MS, Ashley RE, Makhov AM, Conway JF &amp; Hafenstein S (2013) The enterovirus 71 A-particle forms a gateway to allow genome release: a cryoem study of picornavirus uncoating. PLoS Pathog 9: e1003240. PMCID: PMC3605244. DOI: <a class=\"id-link\" href=\"https:\/\/doi.org\/10.1371\/journal.ppat.1003240\" target=\"_blank\" rel=\"noopener\" data-ga-category=\"full_text\" data-ga-action=\"DOI\">10.1371\/journal.ppat.1003240<\/a><\/li>\n<li>Homa FL, Huffman JB, Toropova K, Lopez HR, Makhov AM &amp; Conway JF (2013) Structure of the pseudorabies virus capsid: comparison with herpes simplex virus type 1 and differential binding of essential minor proteins. J Mol Biol 425, 3415-3428. PMCID: PMC3779361. DOI: <a class=\"id-link\" href=\"https:\/\/doi.org\/10.1016\/j.jmb.2013.06.034\" target=\"_blank\" rel=\"noopener noreferrer\">10.1016\/j.jmb.2013.06.034<\/a><\/li>\n<li>Toropova K, Huffman JB, Homa FL &amp; Conway JF (2011) The herpes simplex virus 1 UL17 protein is the second constituent of the capsid vertex-specific component required for DNA packaging and retention. J Virol 85, 7513-7522. PMCID: PMC3147944. DOI: <a class=\"id-link\" href=\"https:\/\/doi.org\/10.1128\/jvi.00837-11\" target=\"_blank\" rel=\"noopener noreferrer\">10.1128\/JVI.00837-11<\/a><\/li>\n<li>Watts NR, Conway JF, Cheng N, Stahl SJ, Steven AC &amp; Wingfield PT (2011) \u00a0Role of the propeptide in controlling conformation and assembly state of hepatitis B virus e-antigen. J Mol Biol 409, 202-213. PMCID: PMC3095675. DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.jmb.2011.03.049\" target=\"_blank\" rel=\"noopener noreferrer\">10.1016\/j.jmb.2011.03.049<\/a><\/li>\n<li>Conway JF, Watts NR, Belnap DM, Cheng N, Stahl SJ, Wingfield PT &amp; Steven AC (2003) Characterization of a conformational epitope on hepatitis B virus core antigen and quasiequivalent variations in antibody binding. J Virol 77, 6466-6473. PMCID: PMC155010. DOI: <a href=\"https:\/\/doi.org\/10.1128\/jvi.77.11.6466-6473.2003\" target=\"_blank\" rel=\"noopener noreferrer\">10.1128\/jvi.77.11.6466-6473.2003<\/a><\/li>\n<li>Conway JF, Wikoff WR, Cheng N, Duda RL, Hendrix RW, Johnson JE &amp; Steven AC (2001) Virus maturation involving large subunit rotations and local refolding. Science 292, 744-748. PMID: 11326105. DOI: <a href=\"https:\/\/doi.org\/10.1126\/science.1058069\" target=\"_blank\" rel=\"noopener noreferrer\">10.1126\/science.1058069<\/a><\/li>\n<li>Conway JF &amp; Steven AC (1999) Methods for reconstructing density maps of single particles from cryoelectron micrographs to subnanometer resolution. J Struct Biol 128, 106-118. PMID: 10600565. DOI: <a href=\"https:\/\/doi.org\/10.1006\/jsbi.1999.4168\" target=\"_blank\" rel=\"noopener noreferrer\">10.1006\/jsbi.1999.4168<\/a><\/li>\n<li>Conway JF, Cheng N, Zlotnick A, Wingfield PT, Stahl SJ &amp; Steven AC (1997) Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryo-electron microscopy. Nature 386, 91-94, PMID: 9052787. DOI: <a href=\"https:\/\/doi.org\/10.1038\/386091a0\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/386091a0<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Full List &lt;link&gt; Belford AK, Maurer JB, Duda RL, Huet A, Conway JF. (2025) Structural insights into scaffold-guided assembly of the Pseudomonas phage D3 capsid. Nat Commun 16, 11586. PMCID: PMC12749128. doi: 10.1038\/s41467-025-66648-1 Huang H, Mu Y, Yixian Y, Ji B, Wang Y, Chen C-Y, Chen Y, Luo Z, Li S, Zhang Z, Wang L, &#8230; <a title=\"Publications\" class=\"read-more\" href=\"https:\/\/conwaylab.structbio.pitt.edu\/index.php\/publications\/\" aria-label=\"Read more about Publications\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-15","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/conwaylab.structbio.pitt.edu\/index.php\/wp-json\/wp\/v2\/pages\/15","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/conwaylab.structbio.pitt.edu\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/conwaylab.structbio.pitt.edu\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/conwaylab.structbio.pitt.edu\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/conwaylab.structbio.pitt.edu\/index.php\/wp-json\/wp\/v2\/comments?post=15"}],"version-history":[{"count":20,"href":"https:\/\/conwaylab.structbio.pitt.edu\/index.php\/wp-json\/wp\/v2\/pages\/15\/revisions"}],"predecessor-version":[{"id":295,"href":"https:\/\/conwaylab.structbio.pitt.edu\/index.php\/wp-json\/wp\/v2\/pages\/15\/revisions\/295"}],"wp:attachment":[{"href":"https:\/\/conwaylab.structbio.pitt.edu\/index.php\/wp-json\/wp\/v2\/media?parent=15"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}